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Article

Premature aggregation of type IV collagen and early lethality in lysyl hydroxylase 3 null mice.

Proceedings of the National Academy of Sciences of the United States of America - 28 Sept 2004

Rautavuoma Kati, Takaluoma Kati, Sormunen Raija, Myllyharju Johanna, Kivirikko Kari I, Soininen Raija

Abstract excerpt

Collagens carry hydroxylysine residues that act as attachment sites for carbohydrate units and are important for the stability of crosslinks but have been regarded as nonessential for vertebrate survival. We generated mice with targeted inactivation of the gene for one of the three lysyl hydroxylase isoenzymes, LH3. The null embryos developed seemingly normally until embryonic day 8.5, but development was then...

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PMID: 15377789
DOI: 10.1073/pnas.0404966101
PMCID: PMC521128

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Premature aggregation of type IV collagen and early lethality in lysyl hydroxylase 3 null mice.PMID 15377789Read ↗

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