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Article

Derlin-1 deficiency is embryonic lethal, Derlin-3 deficiency appears normal, and Herp deficiency is intolerant to glucose load and ischemia in mice.

PloS one - 1 Jan 2012

Eura Yuka, Yanamoto Hiroji, Arai Yuji, Okuda Tomohiko, Miyata Toshiyuki, Kokame Koichi

Abstract excerpt

Accumulation of unfolded or misfolded proteins in the endoplasmic reticulum (ER) causes a cellular condition called ER stress. To overcome ER stress, unfolded proteins are eliminated by an ER-associated degradation (ERAD) system. To explore the physiological requirements for ERAD-related membrane proteins in mammals, we generated Derlin-1-, Derlin-3-, and Herp-deficient mice by gene targeting. Complete loss of...

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Identifiers

PMID: 22479592
DOI: 10.1371/journal.pone.0034298
PMCID: PMC3315519

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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