Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Methylenetetrahydrofolate reductase and thymidylate synthase polymorphisms are not associated with breast cancer risk or phenotype.

Anticancer research - 1 Jan 2000

Grieu Fabienne, Powell Brenda, Beilby John, Iacopetta Barry

Abstract excerpt

BACKGROUND: Aberrations in folate metabolism contribute to the risk of cancer via effects on the synthesis, methylation and repair of DNA. Functional genetic variants in the methylene tetrahydrofolate reductase (MTHFR) and thymidylate synthase (TS) genes may be risk factors for breast cancer because of their central roles in cellular folate metabolism. PATIENTS AND METHODS: The MTHFR C677T and TS tandem repeat...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adolescent
Share to Aged, 80 and over
Share to Breast Neoplasms

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Case-Control Studies

Share to Methylenetetrahydrofolate Reductase (NADPH2)

Share to Polymorphism, Genetic

Share to Polymorphism, Single-Stranded Conformational

Share to Thymidylate Synthase

Source

Identifiers

PMID: 15510613

Genes

MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Methylenetetrahydrofolate reductase and thymidylate synthase polymorphisms are not associated with breast cancer risk or phenotype.PMID 15510613Read ↗

The common 677C>T gene polymorphism of methylenetetrahydrofolate reductase gene is not associated with breast cancer risk.Semantic proximity Read ↗

Polymorphisms in folate metabolizing enzymes and transport proteins and the risk of breast cancer.Semantic proximity Read ↗

Lack of association between methylenetetrahydrofolate reductase genetic polymorphisms and postmenopausal breast cancer risk.Semantic proximity Read ↗

No association between cSHMT genotypes and the risk of breast cancer in the Nurses' Health Study.Semantic proximity Read ↗

No association between methylenetetrahydrofolate reductase C677T polymorphism and breast cancer.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase polymorphism and susceptibility to breast cancer.Semantic proximity Read ↗

Germ-line variants in methyl-group metabolism genes and susceptibility to DNA methylation in human breast cancer.Semantic proximity Read ↗

A functional promoter polymorphism in the TERT gene does not affect inherited susceptibility to breast cancer.Semantic proximity Read ↗

MTHFR genotypes and breast cancer survival after surgery and chemotherapy: a report from the Shanghai Breast Cancer Study.Semantic proximity Read ↗

Influence of thymidylate synthase and methylenetetrahydrofolate reductase gene polymorphisms on the disease-free survival of breast cancer patients receiving adjuvant 5-fluorouracil/methotrexate-based therapy.Semantic proximity Read ↗

Reduced breast cancer risk with increasing serum folate in a case-control study of the C677T genotype of the methylenetetrahydrofolate reductase gene.Semantic proximity Read ↗

[Polymorphic variants of folate metabolizing genes (C677T and A1298C MTHFR, C1420T SHMT1 and G1958A MTHFD) are not associated with the risk of breast cancer in West Siberian Region of Russia].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.