Polymorphisms in folate metabolizing enzymes and transport proteins and the risk of breast cancer.

doi:10.1007/s10549-008-9895-6

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Article

Polymorphisms in folate metabolizing enzymes and transport proteins and the risk of breast cancer.

Breast cancer research and treatment - 1 Dec 2008

Kotsopoulos Joanne, Zhang William W, Zhang Shiyu, McCready David, Trudeau Maureen, Zhang Phil, Sun Ping, Narod Steven A

Abstract excerpt

BACKGROUND: An accumulating body of evidence suggests that there is an inverse relationship between the intake of folate (a water-soluble B-vitamin) and the risk of developing breast cancer. Individual variation in the genes involved in the transport of folate, or its metabolism, may affect risk, or may modify the association between folate and breast cancer risk. METHODS: We performed a case-control study to...

Topics

Adult
Aged
Breast Neoplasms
Case-Control Studies
Female
Folic Acid
Gene Frequency
Genetic Variation
Genotype
Humans
Middle Aged
Mutation
Odds Ratio
Polymorphism, Single Nucleotide
Risk

Source

Open in PubMed

Identifiers

PMID: 18204969
DOI: 10.1007/s10549-008-9895-6

Genes

MTHFR
MTRR

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