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MTHFR genotypes and breast cancer survival after surgery and chemotherapy: a report from the Shanghai Breast Cancer Study.

Breast cancer research and treatment - 1 May 2005

Shrubsole Martha J, Shu Xiao Ou, Ruan Zhi Xian, Cai Qiuyin, Cai Hui, Niu Qi, Gao Yu-Tang, Zheng Wei

Abstract excerpt

Methylenetetrahydrofolate reductase (MTHFR) regulates the intracellular folates pool for DNA synthesis and methylation. Sequence variations in MTHFR (nucleotides 677 (C-->T) and 1298 (A-->C)) result in allozymes with decreased activity. The 677TT genotype is associated with increased toxicity of methotrexate and increased clinical response to 5-fluorouracil in treatment of cancers including breast cancer. We...

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Identifiers

PMID: 15868433
DOI: 10.1007/s10549-004-7265-6

Genes

MTHFR

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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