Article
Influence of thymidylate synthase and methylenetetrahydrofolate reductase gene polymorphisms on the disease-free survival of breast cancer patients receiving adjuvant 5-fluorouracil/methotrexate-based therapy.
Anti-cancer drugs - 1 Aug 2007
Paré Laia, Altés Albert, Ramón y Cajal Teresa, Del Rio Elisabeth, Alonso Carmen, Sedano Lidia, Barnadas Agusti, Baiget Montserrat
Abstract excerpt
This paper considers the influence of thymidylate synthase (TS) and methylenetetrahydrofolate reductase (MTHFR) polymorphisms on the disease-free survival of patients with breast cancer who were treated with adjuvant therapy containing 5-fluorouracil. Relevant clinical data were obtained from the clinical records of 93 patients included in the study. TS and MTHFR genotypes were determined by PCR-agarose gel...
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