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Article

No association between methylenetetrahydrofolate reductase C677T polymorphism and breast cancer.

Cell biochemistry and function - 1 Jan 2000

Hekim Nezih, Ergen Arzu, Yaylim Ilhan, Yilmaz Hülya, Zeybek Umit, Oztürk Oğuz, Isbir Turgay

Abstract excerpt

Methylenetetrahydrofolate reductase (MTHFR) is an enzyme (EC 1.5.1.20), that reduces 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a carbon donor for the homocysteine to methionine conversion. MTHFR is a key enzyme that regulates folate metabolism which has an important role in DNA synthesis, DNA repair and methylation. The association between MTHFR C677T polymorphism and breast cancer has been...

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Source

Identifiers

PMID: 16134079
DOI: 10.1002/cbf.1274

Genes

MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

No association between methylenetetrahydrofolate reductase C677T polymorphism and breast cancer.PMID 16134079Read ↗

Association of the MTHFR Gene C677T Polymorphism with Breast Cancer in a Turkish Population.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase polymorphisms and breast cancer risk: a meta-analysis from 41 studies with 16,480 cases and 22,388 controls.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase gene C677T polymorphism and breast cancer risk: Evidence for genetic susceptibilitySemantic proximity Read ↗

The methylenetetrahydrofolate reductase C677T polymorphism and breast cancer risk in Asian populations.Semantic proximity Read ↗

Lack of association between methylenetetrahydrofolate reductase gene A1298C polymorphism and breast cancer susceptibility.Semantic proximity Read ↗

The association between methylenetetrahydrofolate reductase gene C677T polymorphisms and breast cancer risk in Chinese population.Semantic proximity Read ↗

MTHFR 677C>T polymorphism and the risk of breast cancer: evidence from an original study and pooled data for 28031 cases and 31880 controls.Semantic proximity Read ↗

Association between the MTHFR C677T Polymorphism and Breast Cancer Risk: A Meta-Analysis of 23 Case-Control Studies.Semantic proximity Read ↗

MTHFR C677T polymorphism associated with breast cancer susceptibility: a meta-analysis involving 15,260 cases and 20,411 controls.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase polymorphisms and breast cancer risk in Chinese population: a meta-analysis of 22 case-control studies.Semantic proximity Read ↗

Homozygosity at the C677T of the MTHFR gene is associated with increased breast cancer risk in the Turkish population.Semantic proximity Read ↗

Association of Intake Folate and Related Gene Polymorphisms with Breast Cancer.Semantic proximity Read ↗

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