Article
The common 677C>T gene polymorphism of methylenetetrahydrofolate reductase gene is not associated with breast cancer risk.
Breast cancer research and treatment - 1 Sept 2003
Langsenlehner Uwe, Krippl Peter, Renner Wilfried, Yazdani-Biuki Babak, Wolf Gerald, Wascher Thomas C, Paulweber Bernhard, Weitzer Werner, Samonigg Hellmut
Abstract excerpt
Methylenetetrahydrofolate reductase (MTHFR) is involved in folate metabolism and plays a role in DNA biosynthesis, methylation, and repair in actively dividing cells. A common 677C>T polymorphism in the gene for MTHFR, leading to a thermolabile enzyme with decreased activity, has been associated with reduced plasma folate levels and elevated homocysteine levels and could be a risk factor for breast cancer. In the...
Topics
- Adult
- Aged
- Aged, 80 and over
- Breast Neoplasms
- Carcinoma, Ductal, Breast
- Case-Control Studies
- Cytosine
- Female
- Genotype
- Humans
- Methylenetetrahydrofolate Reductase (NADPH2)