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Article

The common 677C>T gene polymorphism of methylenetetrahydrofolate reductase gene is not associated with breast cancer risk.

Breast cancer research and treatment - 1 Sept 2003

Langsenlehner Uwe, Krippl Peter, Renner Wilfried, Yazdani-Biuki Babak, Wolf Gerald, Wascher Thomas C, Paulweber Bernhard, Weitzer Werner, Samonigg Hellmut

Abstract excerpt

Methylenetetrahydrofolate reductase (MTHFR) is involved in folate metabolism and plays a role in DNA biosynthesis, methylation, and repair in actively dividing cells. A common 677C>T polymorphism in the gene for MTHFR, leading to a thermolabile enzyme with decreased activity, has been associated with reduced plasma folate levels and elevated homocysteine levels and could be a risk factor for breast cancer. In the...

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Identifiers

PMID: 14572159
DOI: 10.1023/A:1025752420309

Genes

MTHFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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The common 677C>T gene polymorphism of methylenetetrahydrofolate reductase gene is not associated with breast cancer risk.PMID 14572159Read ↗

Methylenetetrahydrofolate reductase and thymidylate synthase polymorphisms are not associated with breast cancer risk or phenotype.Semantic proximity Read ↗

No association between methylenetetrahydrofolate reductase C677T polymorphism and breast cancer.Semantic proximity Read ↗

Lack of association between methylenetetrahydrofolate reductase genetic polymorphisms and postmenopausal breast cancer risk.Semantic proximity Read ↗

Homozygosity at the C677T of the MTHFR gene is associated with increased breast cancer risk in the Turkish population.Semantic proximity Read ↗

MTHFR 677C>T polymorphism and the risk of breast cancer: evidence from an original study and pooled data for 28031 cases and 31880 controls.Semantic proximity Read ↗

Lack of association between methylenetetrahydrofolate reductase gene A1298C polymorphism and breast cancer susceptibility.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C polymorphisms in breast cancer: a Sardinian preliminary case-control studySemantic proximity Read ↗

Reduced breast cancer risk with increasing serum folate in a case-control study of the C677T genotype of the methylenetetrahydrofolate reductase gene.Semantic proximity Read ↗

Polymorphisms in the MTHFR gene are associated with breast cancer.Semantic proximity Read ↗

A common mutation in methylenetetrahydrofolate reductase gene is not a major risk of coronary artery disease or myocardial infarction.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase polymorphism and susceptibility to breast cancer.Semantic proximity Read ↗

Polymorphisms in folate metabolizing enzymes and transport proteins and the risk of breast cancer.Semantic proximity Read ↗

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