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Article

A functional promoter polymorphism in the TERT gene does not affect inherited susceptibility to breast cancer.

Cancer genetics and cytogenetics - 15 Apr 2009

Varadi Verena, Brendle Annika, Grzybowska Ewa, Johansson Robert, Enquist Kerstin, Butkiewicz Dorota, Pamula-Pilat Jolanta, Pekala Wioletta, Hemminki Kari, Lenner Per, Försti Asta

Abstract excerpt

Telomere dysfunction is a key mechanism in cancer development. The human telomerase reverse transcriptase (TERT) is the rate-limiting catalytic subunit of the telomerase enzyme, which is necessary for the maintenance of telomere DNA length, chromosomal stability, and cellular immortality. In our attempt to identify functional polymorphisms in the TERT gene and their effect on breast cancer risk, we sequenced the...

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Source

Identifiers

PMID: 19380022
DOI: 10.1016/j.cancergencyto.2008.12.006

Genes

TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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A functional promoter polymorphism in the TERT gene does not affect inherited susceptibility to breast cancer.PMID 19380022Read ↗

Polymorphisms in the telomerase reverse transcriptase promoter are associated with risk of breast cancer: A meta-analysis.Semantic proximity Read ↗

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Frequency of TERT promoter mutations in human cancersSemantic proximity Read ↗

Lack of association between common single nucleotide polymorphisms in the TERT-CLPTM1L locus and breast cancer in women of African ancestry.Semantic proximity Read ↗

Methylenetetrahydrofolate reductase and thymidylate synthase polymorphisms are not associated with breast cancer risk or phenotype.Semantic proximity Read ↗

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