Article
Multiple defects in translation associated with altered ribosomal protein L4.
Nucleic acids research - 1 Jan 2004
O'Connor Michael, Gregory Steven T, Dahlberg Albert E
Abstract excerpt
The ribosomal proteins L4 and L22 form part of the peptide exit tunnel in the large ribosomal subunit. In Escherichia coli, alterations in either of these proteins can confer resistance to the macrolide antibiotic, erythromycin. The structures of the 30S as well as the 50S subunits from each antibiotic resistant mutant differ from wild type in distinct ways and L4 mutant ribosomes have decreased peptide...
Topics
- Codon
- Codon, Terminator
- Erythromycin
- Escherichia coli
- Frameshifting, Ribosomal
- Mutation
- Mutation, Missense
- Protein Biosynthesis
- Protein Synthesis Inhibitors
- RNA, Messenger
- RNA, Transfer, Met
- Ribosomal Proteins
- Ribosomes