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Article

Erythromycin resistance mutations in ribosomal proteins L22 and L4 perturb the higher order structure of 23 S ribosomal RNA.

Journal of molecular biology - 18 Jun 1999

Gregory S T, Dahlberg A E

Abstract excerpt

We have used chemical modification to examine the conformation of 23 S rRNA in Escherichia coli ribosomes bearing erythromycin resistance mutations in ribosomal proteins L22 and L4. Changes in reactivity to chemical probes were observed at several nucleotide positions scattered throughout 23 S rRNA. The L4 mutation affects the reactivity of G799 and U1255 in domain II and that of A2572 in domain V. The L22...

Topics

Drug Resistance, Microbial
Erythromycin
Escherichia coli
Escherichia coli Proteins
Mutation
Nucleic Acid Conformation
RNA, Bacterial
RNA, Ribosomal, 23S
RNA-Binding Proteins
Ribosomal Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 10369764
DOI: 10.1006/jmbi.1999.2839

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Erythromycin resistance mutations in ribosomal proteins L22 and L4 perturb the higher order structure of 23 S ribosomal RNA.PMID 10369764Read ↗

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