Article
The Ribosomal Protein uL22 Modulates the Shape of the Protein Exit Tunnel.
Structure (London, England : 1993) - 1 Aug 2017
Wekselman Itai, Zimmerman Ella, Davidovich Chen, Belousoff Matthew, Matzov Donna, Krupkin Miri, Rozenberg Haim, Bashan Anat, Friedlander Gilgi, Kjeldgaard Jette, Ingmer Hanne, Lindahl Lasse, Zengel Janice M, Yonath Ada
Abstract excerpt
Erythromycin is a clinically useful antibiotic that binds to an rRNA pocket in the ribosomal exit tunnel. Commonly, resistance to erythromycin is acquired by alterations of rRNA nucleotides that interact with the drug. Mutations in the β hairpin of ribosomal protein uL22, which is rather distal to the erythromycin binding site, also generate resistance to the antibiotic. We have determined the crystal structure...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.