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Article

Erythromycin resistance by L4/L22 mutations and resistance masking by drug efflux pump deficiency.

The EMBO journal - 18 Mar 2009

Lovmar Martin, Nilsson Karin, Lukk Eliisa, Vimberg Vladimir, Tenson Tanel, Ehrenberg Måns

Abstract excerpt

We characterized the effects of classical erythromycin resistance mutations in ribosomal proteins L4 and L22 of the large ribosomal subunit on the kinetics of erythromycin binding. Our data are consistent with a mechanism in which the macrolide erythromycin enters and exits the ribosome through the nascent peptide exit tunnel, and suggest that these mutations both impair passive transport through the tunnel and...

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Identifiers

PMID: 19197244
DOI: 10.1038/emboj.2009.17
PMCID: PMC2666033

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Source receipt: pubmed, retrieved 7 Sept 2026.

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