Article
Novel mutations in ribosomal proteins L4 and L22 that confer erythromycin resistance in Escherichia coli.
Molecular microbiology - 1 Nov 2007
Zaman Sephorah, Fitzpatrick Megan, Lindahl Lasse, Zengel Janice
Abstract excerpt
L4 and L22, proteins of the large ribosomal subunit, contain globular surface domains and elongated 'tentacles' that reach into the core of the large subunit to form part of the lining of the peptide exit tunnel. Mutations in the tentacles of L4 and L22 confer macrolide resistance in a variety of pathogenic and non-pathogenic bacteria. In Escherichia coli, a Lys-to-Glu mutation in L4 and a three-amino-acid...
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