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Article

Neonatal lethality of LGR5 null mice is associated with ankyloglossia and gastrointestinal distension.

Molecular and cellular biology - 1 Nov 2004

Morita Hiroki, Mazerbourg Sabine, Bouley Donna M, Luo Ching-Wei, Kawamura Kazuhiro, Kuwabara Yoshimitsu, Baribault Helene, Tian Hui, Hsueh Aaron J W

Abstract excerpt

The physiological role of an orphan G protein-coupled receptor, LGR5, was investigated by targeted deletion of this seven-transmembrane protein containing a large N-terminal extracellular domain with leucine-rich repeats. LGR5 null mice exhibited 100% neonatal lethality characterized by gastrointestinal tract dilation with air and an absence of milk in the stomach. Gross and histological examination revealed...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15509778
DOI: 10.1128/MCB.24.22.9736-9743.2004
PMCID: PMC525477

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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