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Article

Dysphagia and disrupted cranial nerve development in a mouse model of DiGeorge (22q11) deletion syndrome.

Disease models & mechanisms - 1 Feb 2014

Karpinski Beverly A, Maynard Thomas M, Fralish Matthew S, Nuwayhid Samer, Zohn Irene E, Moody Sally A, LaMantia Anthony-S

Abstract excerpt

We assessed feeding-related developmental anomalies in the LgDel mouse model of chromosome 22q11 deletion syndrome (22q11DS), a common developmental disorder that frequently includes perinatal dysphagia--debilitating feeding, swallowing and nutrition difficulties from birth onward--within its phenotypic spectrum. LgDel pups gain significantly less weight during the first postnatal weeks, and have several signs of...

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Identifiers

PMID: 24357327
DOI: 10.1242/dmm.012484
PMCID: PMC3917245

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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