Article
Dysphagia and disrupted cranial nerve development in a mouse model of DiGeorge (22q11) deletion syndrome.
Disease models & mechanisms - 1 Feb 2014
Karpinski Beverly A, Maynard Thomas M, Fralish Matthew S, Nuwayhid Samer, Zohn Irene E, Moody Sally A, LaMantia Anthony-S
Abstract excerpt
We assessed feeding-related developmental anomalies in the LgDel mouse model of chromosome 22q11 deletion syndrome (22q11DS), a common developmental disorder that frequently includes perinatal dysphagia--debilitating feeding, swallowing and nutrition difficulties from birth onward--within its phenotypic spectrum. LgDel pups gain significantly less weight during the first postnatal weeks, and have several signs of...
Topics
- Animals
- Animals, Newborn
- Body Patterning
- Chromosome Deletion
- Cranial Nerves
- Craniofacial Abnormalities
- Deglutition
- Deglutition Disorders
- DiGeorge Syndrome
- Disease Models, Animal