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LGR4 and LGR5 Function Redundantly During Human Endoderm Differentiation

22 Jun 2016

Abstract excerpt

Background & Aims The Lgr family of transmembrane proteins (Lgr4, 5, 6) act as functional receptors for R-spondin proteins (Rspo 1, 2, 3, 4), and potentiate Wnt signaling in different contexts. Lgr5 is arguably the best characterized of the Lgr family members in a number of adult and embryonic contexts in mice. However, the function of LGR family members in early embryonic development is unclear, and has not been...

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PMID: 28078320
DOI: 10.1016/j.jcmgh.2016.06.002

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