Article
Dlx5 regulates regional development of the branchial arches and sensory capsules.
Development (Cambridge, England) - 1 Sept 1999
Depew M J, Liu J K, Long J E, Presley R, Meneses J J, Pedersen R A, Rubenstein J L
Abstract excerpt
We report the generation and analysis of mice homozygous for a targeted deletion of the Dlx5 homeobox gene. Dlx5 mutant mice have multiple defects in craniofacial structures, including their ears, noses, mandibles and calvaria, and die shortly after birth. A subset (28%) exhibit exencephaly. Ecto...
Topics
- Animals
- Animals, Newborn
- Base Sequence
- Branchial Region
- Craniofacial Abnormalities
- DNA Primers
- Ear, Inner
- Facial Bones
- Gene Expression Regulation, Developmental
- Genes, Homeobox
- Homeodomain Proteins
- In Situ Hybridization