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Functional roles of Lgr4 and Lgr5 in embryonic gut, kidney and skin development in mice.

Developmental biology - 15 Jun 2014

Kinzel Bernd, Pikiolek Monika, Orsini Vanessa, Sprunger Joëlle, Isken Andrea, Zietzling Svenja, Desplanches Magali, Dubost Valerie, Breustedt Daniel, Valdez Reginald, Liu Dong, Theil Diethilde, Müller Matthias, Dietrich Bill, Bouwmeester Tewis, Ruffner Heinz, Tchorz Jan S

Abstract excerpt

Lgr4 and Lgr5 are known markers of adult and embryonic tissue stem cells in various organs. However, whether Lgr4 and Lgr5 are important for embryonic development remains unclear. To study their functions during intestinal crypt, skin and kidney development we now generated mice lacking either Lgr4 (Lgr4KO), Lgr5 (Lgr5KO) or both receptors (Lgr4/5dKO). E16.5 Lgr4KO mice displayed complete loss of...

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PMID: 24680895
DOI: 10.1016/j.ydbio.2014.03.009

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