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Article

The AP1 transcription factor Fra2 is required for efficient cartilage development

28 Oct 2004

Abstract excerpt

The Fos-related AP1 transcription factor Fra2 (encoded by Fosl2) is expressed in various epithelial cells as well as in cartilaginous structures. We studied the role of Fra2 in cartilage development. The absence of Fra2 in embryos and newborns leads to reduced zones of hypertrophic chondrocytes and impaired matrix deposition in femoral and tibial growth plates, probably owing to impaired differentiation into...

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PMID: 15509771
DOI: 10.1242/dev.01414

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