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THE ROLE OF ACTIVATING TRANSCRIPTION FACTOR-2 IN SKELETAL GROWTH CONTROL

1 Jan 2003

Abstract excerpt

The growth plate is a dynamic area of cells that directs longitudinal bone growth and endochondral ossification by virtue of the progression of chondrocytes through the proliferation, maturation, and hypertrophic stages of cell differentiation. The initiation of growth-plate chondrocyte proliferation is stimulated by growth-hormone-induced IGF-1 1, followed by rapid clonal proliferation in response to a variety...

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PMID: 12721356
DOI: 10.2106/00004623-200300002-00018

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