Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Development of pulmonary fibrosis through a pathway involving the transcription factor Fra-2/AP-1

18 Jul 2008

Abstract excerpt

Studies using genetically modified mice have revealed fundamental functions of the transcription factor Fos/AP-1 in bone biology, inflammation, and cancer. However, the biological role of the Fos-related protein Fra-2 is not well defined in vivo. Here we report an unexpected profibrogenic function of Fra-2 in transgenic mice, in which ectopic expression of Fra-2 in various organs resulted in generalized fibrosis...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Share to Medical Imaging and Pathology Studies
Share to Pulmonary Hypertension Research and Treatments

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 18641127
DOI: 10.1073/pnas.0801414105

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 20 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Development of pulmonary fibrosis through a pathway involving the transcription factor Fra-2/AP-1PMID 18641127Read ↗

The Fra-1: Novel role in regulating extensive immune cell states and affecting inflammatory diseasesSemantic proximity Read ↗

Expression profiling of genes regulated by Fra-1/AP-1 transcription factor during bleomycin-induced pulmonary fibrosisSemantic proximity Read ↗

Activator protein 1 (Fos/Jun) functions in inflammatory bone and skin diseaseSemantic proximity Read ↗

Fra-2/AP-1 controls bone formation by regulating osteoblast differentiation and collagen production.Semantic proximity Read ↗

The AP1 transcription factor Fra2 is required for efficient cartilage developmentSemantic proximity Read ↗

A systematic comparison of FOSL1, FOSL2 and BATF-mediated transcriptional regulation during early human Th17 differentiationSemantic proximity Read ↗

Role of Fra-2 in cancerSemantic proximity Read ↗

Heterotopic ossification in mice overexpressing Bmp2 in Tie2+ lineagesSemantic proximity Read ↗

The AP1 Transcription Factor Fosl2 Promotes Systemic Autoimmunity and Inflammation by Repressing Treg Development.Semantic proximity Read ↗

Developmental Expression of Transforming Growth Factor Induced Protein Promotes NF-Kappa-B Mediated Angiogenesis During Postnatal Lung DevelopmentSemantic proximity Read ↗

FIZZ2/RELM-β Induction and Role in Pulmonary FibrosisSemantic proximity Read ↗

The F2-Isoprostane:Thromboxane-prostanoid receptor signaling axis drives persistent fibroblast activation in pulmonary fibrosisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.