Article
Classical photoreceptors regulate melanopsin mRNA levels in the rat retina.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 27 Oct 2004
Sakamoto Katsuhiko, Liu Cuimei, Tosini Gianluca
Abstract excerpt
Recent studies have demonstrated that melanopsin is a key photopigment in the mammalian circadian system. This novel opsin is exclusively expressed in retinal ganglion cells that are intrinsically sensitive to light, perhaps responding via a melanopsin-based signaling pathway. Previous investigations using transgenic mice have also demonstrated that ablation of the classical photoreceptors and of melanopsin...
Topics
- Animals
- Circadian Rhythm
- Gene Expression Regulation
- Mutation
- Nerve Growth Factors
- Neuropeptides
- Neurotransmitter Agents
- Photoreceptor Cells, Vertebrate
- Pituitary Adenylate Cyclase-Activating Polypeptide
- Proto-Oncogene Proteins
- RNA, Messenger
- Rats
- Receptor Protein-Tyrosine Kinases