Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inner retinal photoreception independent of the visual retinoid cycle.

Proceedings of the National Academy of Sciences of the United States of America - 5 Jul 2006

Tu Daniel C, Owens Leah A, Anderson Lauren, Golczak Marcin, Doyle Susan E, McCall Maureen, Menaker Michael, Palczewski Krzysztof, Van Gelder Russell N

Abstract excerpt

Mice lacking the visual cycle enzymes RPE65 or lecithin-retinol acyl transferase (Lrat) have pupillary light responses (PLR) that are less sensitive than those of mice with outer retinal degeneration (rd/rd or rdta). Inner retinal photoresponses are mediated by melanopsin-expressing, intrinsically photosensitive retinal ganglion cells (ipRGCs), suggesting that the melanopsin-dependent photocycle utilizes RPE65...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to cis-trans-Isomerases
Share to Eye Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Nerve Degeneration

Share to Retina

Share to Retinal Ganglion Cells

Share to Retinoids

Share to Rod Opsins

Share to Vision, Ocular

Source

Open in PubMed Open full text

Identifiers

PMID: 16788071
DOI: 10.1073/pnas.0600917103
PMCID: PMC1502474

Genes

RPE65

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inner retinal photoreception independent of the visual retinoid cycle.PMID 16788071Read ↗

Effect of circadian clock gene mutations on nonvisual photoreception in the mouse.Semantic proximity Read ↗

RPE Visual Cycle and Biochemical Phenotypes of Mutant Mouse Models.Semantic proximity Read ↗

Pathways and disease-causing alterations in visual chromophore production for vertebrate visionSemantic proximity Read ↗

Protection of Rpe65-deficient mice identifies rhodopsin as a mediator of light-induced retinal degenerationSemantic proximity Read ↗

Characterization of an ocular photopigment capable of driving pupillary constriction in mice.Semantic proximity Read ↗

Nonvisual light responses in the Rpe65 knockout mouse: rod loss restores sensitivity to the melanopsin system.Semantic proximity Read ↗

<i>RPE65</i> knockout <i>Xenopus laevis</i> have a compromised but detectable electroretinogram and altered visual responses, without retinal degeneration or altered melanophore dispersionSemantic proximity Read ↗

Safety and Proof-of-Concept Study of Oral QLT091001 in Retinitis Pigmentosa Due to Inherited Deficiencies of Retinal Pigment Epithelial 65 Protein (RPE65) or Lecithin:Retinol Acyltransferase (LRAT).Semantic proximity Read ↗

Identifying the photoreceptive inputs to the mammalian circadian system using transgenic and retinally degenerate mice.Semantic proximity Read ↗

A History of the Classical Visual Cycle.Semantic proximity Read ↗

Rpe65 is necessary for production of 11-cis-vitamin A in the retinal visual cycle.Semantic proximity Read ↗

Lecithin-retinol acyltransferase is essential for accumulation of all-trans-retinyl esters in the eye and in the liver.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.