Article
Polygenic disease and retinitis pigmentosa: albinism exacerbates photoreceptor degeneration induced by the expression of a mutant opsin in transgenic mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 15 Dec 1996
Naash M I, Ripps H, Li S, Goto Y, Peachey N S
Abstract excerpt
Expression of a mouse opsin transgene containing three point mutations (V20G, P23H, and P27L; termed VPP) causes a progressive photoreceptor degeneration that resembles in many important respects that seen in patients with autosomal dominant retinitis pigmentosa caused by a P23H point mutation. W...
Topics
- Albinism
- Animals
- Densitometry
- Electroretinography
- Gene Expression
- Mice
- Mice, Inbred C57BL
- Mice, Transgenic
- Mutation
- Nerve Degeneration
- Photoreceptor Cells
- Reference Values
- Retina
- Retinitis Pigmentosa
- Rhodopsin