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Article

Nonvisual light responses in the Rpe65 knockout mouse: rod loss restores sensitivity to the melanopsin system.

Proceedings of the National Academy of Sciences of the United States of America - 5 Jul 2006

Doyle Susan E, Castrucci Ana Maria, McCall Maureen, Provencio Ignacio, Menaker Michael

Abstract excerpt

Intrinsically photosensitive retinal ganglion cells (ipRGCs) expressing the photopigment melanopsin (OPN4), together with rods and cones, provide light information driving nonvisual light responses. We examined nonvisual photoreception in mice lacking RPE65, a protein that is required for regeneration of visual chromophore in rods and cones. Although Rpe65 knockouts retain a small degree of rod function, we show...

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Source

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Identifiers

PMID: 16788070
DOI: 10.1073/pnas.0600934103
PMCID: PMC1502475

Genes

RPE65
OPN4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Nonvisual light responses in the Rpe65 knockout mouse: rod loss restores sensitivity to the melanopsin system.PMID 16788070Read ↗

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