Article
Identifying the photoreceptive inputs to the mammalian circadian system using transgenic and retinally degenerate mice.
Behavioural brain research - 1 Nov 2001
Lucas R J, Freedman M S, Lupi D, Munoz M, David-Gray Z K, Foster R G
Abstract excerpt
The endogenous circadian clock of mammals retains synchrony with the external light:dark cycle through ocular photoreceptors. To date the identity of the photoreceptors responsible for mediating this response is unknown. This review outlines attempts using transgenic mouse models to address this deficit. Mice bearing specific inherited lesions of both rod and cone photoreceptors retain circadian photosensitivity...
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