Article

Metabolic regulation of copper homeostasis governs the Sec61-dependent protein translocation process in <i>Saccharomyces cerevisiae</i>

2025-08-04

Abstract excerpt

Concentration of cellular labile pool of copper must be strictly regulated because disruption in copper homeostasis results in diseases. In Saccharomyces cerevisiae , elevated levels of labile copper impair cell viability by inhibiting Sec61-mediated protein translocation into the endoplasmic reticulum. We investigated how metabolic pathways, specifically mitochondrial respiration and autophagy, contribute to cop...

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Literature Corpus work: 0a432290-fd54-5628-a8aa-d82e5659ab7c
DOI: 10.1101/2025.08.03.668358

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