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Identification of genes involved in the toxic response of Saccharomyces cerevisiae against iron and copper overload by parallel analysis of deletion mutants.

Toxicological sciences : an official journal of the Society of Toxicology - 1 Jan 2008

Jo William J, Loguinov Alex, Chang Michelle, Wintz Henri, Nislow Corey, Arkin Adam P, Giaever Guri, Vulpe Chris D

Abstract excerpt

Iron and copper are essential nutrients for life as they are required for the function of many proteins but can be toxic if present in excess. Accumulation of these metals in the human body as a consequence of overload disorders and/or high environmental exposures has detrimental effects on health. The budding yeast Saccharomyces cerevisiae is an accepted cellular model for iron and copper metabolism in humans...

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PMID: 17785683
DOI: 10.1093/toxsci/kfm226

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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