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Article

Specific changes in mitochondrial lipidome alter mitochondrial proteome and increase the geroprotective efficiency of lithocholic acid in chronologically aging yeast.

Oncotarget - 9 May 2017

Leonov Anna, Arlia-Ciommo Anthony, Bourque Simon D, Koupaki Olivia, Kyryakov Pavlo, Dakik Paméla, McAuley Mélissa, Medkour Younes, Mohammad Karamat, Di Maulo Tamara, Titorenko Vladimir I

Abstract excerpt

We have previously found that exogenously added lithocholic acid delays yeast chronological aging. We demonstrated that lithocholic acid enters the yeast cell, is sorted to mitochondria, resides in both mitochondrial membranes, changes the relative concentrations of different membrane phospholipids, triggers changes in the concentrations of many mitochondrial proteins, and alters some key aspects of mitochondrial...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28410198
DOI: 10.18632/oncotarget.16766
PMCID: PMC5458158

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