Article
Loss of major nutrient sensing and signaling pathways suppresses starvation lethality in electron transport chain mutants.
Molecular biology of the cell - 1 Dec 2021
Lewis Alisha G, Caldwell Robert, Rogers Jason V, Ingaramo Maria, Wang Rebecca Y, Soifer Ilya, Hendrickson David G, McIsaac R Scott, Botstein David, Gibney Patrick A
Abstract excerpt
The electron transport chain (ETC) is a well-studied and highly conserved metabolic pathway that produces ATP through generation of a proton gradient across the inner mitochondrial membrane coupled to oxidative phosphorylation. ETC mutations are associated with a wide array of human disease conditions and to aging-related phenotypes in a number of different organisms. In this study, we sought to better understand...
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