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Article

Calcineurin A-alpha but not A-beta is required for normal kidney development and function.

The American journal of pathology - 1 Nov 2004

Gooch Jennifer L, Toro Juan J, Guler Rebecca L, Barnes Jeffrey L

Abstract excerpt

Calcineurin is an important signaling molecule in the kidney and may be involved in a variety of processes. The phosphatase subunit of calcineurin (CnA) has three isoforms, alpha, beta, and gamma. In this study, we investigated the effect of loss of calcineurin A-alpha (CnA-alpha) or calcineurin A-beta (CnA-beta) on the development and function of the kidney. Total calcineurin expression and activity was...

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Identifiers

PMID: 15509543
DOI: 10.1016/s0002-9440(10)63430-x
PMCID: PMC1618665

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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