Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Heart-specific Deletion of CnB1 Reveals Multiple Mechanisms Whereby Calcineurin Regulates Cardiac Growth and Function

28 Dec 2009

Abstract excerpt

Calcineurin is a protein phosphatase that is uniquely regulated by sustained increases in intracellular Ca(2+) following signal transduction events. Calcineurin controls cellular proliferation, differentiation, apoptosis, and inducible gene expression following stress and neuroendocrine stimulation. In the adult heart, calcineurin regulates hypertrophic growth of cardiomyocytes in response to pathologic insults...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cardiac Structural Anomalies and Repair
Share to Peptidase Inhibition and Analysis
Share to Signaling Pathways in Disease

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 20037164
DOI: 10.1074/jbc.m109.056143

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Heart-specific Deletion of CnB1 Reveals Multiple Mechanisms Whereby Calcineurin Regulates Cardiac Growth and FunctionPMID 20037164Read ↗

Impaired contractile function and calcium handling in hearts of cardiac-specific calcineurin b1-deficient mice.Semantic proximity Read ↗

Changes in Cx43 and NaV1.5 Expression Precede the Occurrence of Substantial Fibrosis in Calcineurin-Induced Murine Cardiac HypertrophySemantic proximity Read ↗

Mice lacking calsarcin-1 are sensitized to calcineurin signaling and show accelerated cardiomyopathy in response to pathological biomechanical stress.Semantic proximity Read ↗

Calcium cycling proteins in heart failure, cardiomyopathy and arrhythmias.Semantic proximity Read ↗

Murine Creld1 controls cardiac development through activation of calcineurin/NFATc1 signaling.Semantic proximity Read ↗

Cardiac-specific Expression of Calcineurin Reverses Embryonic Lethality in Calreticulin-deficient MouseSemantic proximity Read ↗

Dscr1, a novel endogenous inhibitor of calcineurin signaling, is expressed in the primitive ventricle of the heart and during neurogenesisSemantic proximity Read ↗

A calcineurin–Hoxb13 axis regulates growth mode of mammalian cardiomyocytesSemantic proximity Read ↗

Myocardial Hypertrophic Remodeling and Impaired Left Ventricular Function in Mice with a Cardiac-Specific Deletion of Janus Kinase 2.Semantic proximity Read ↗

Reversibility of adverse, calcineurin-dependent cardiac remodeling.Semantic proximity Read ↗

The CnB1 p.D102A variant is linked to dilated cardiomyopathy via impaired Calcineurin activity.Semantic proximity Read ↗

Impaired cardiac contraction and relaxation and decreased expression of sarcoplasmic Ca2+-ATPase in mice lacking the CREM gene.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.