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Article

Gremlin1 plays a key role in kidney development and renal fibrosis.

American journal of physiology. Renal physiology - 1 Jun 2017

Church Rachel H, Ali Imran, Tate Mitchel, Lavin Deborah, Krishnakumar Arjun, Kok Helena M, Hombrebueno Jose R, Dunne Philip D, Bingham Victoria, Goldschmeding Roel, Martin Finian, Brazil Derek P

Abstract excerpt

Gremlin1 (Grem1), an antagonist of bone morphogenetic proteins, plays a key role in embryogenesis. A highly specific temporospatial gradient of Grem1 and bone morphogenetic protein signaling is critical to normal lung, kidney, and limb development. Grem1 levels are increased in renal fibrotic conditions, including acute kidney injury, diabetic nephropathy, chronic allograft nephropathy, and immune...

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Identifiers

PMID: 28100499
DOI: 10.1152/ajprenal.00344.2016
PMCID: PMC5495891

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TEC

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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