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Article

Terminal renal failure in mice lacking transcription factor AP-2 beta.

Laboratory investigation; a journal of technical methods and pathology - 1 Apr 2003

Moser Markus, Dahmen Sandra, Kluge Reinhart, Gröne Hermann, Dahmen Judith, Kunz Dagmar, Schorle Hubert, Buettner Reinhard

Abstract excerpt

Inactivation of the transcription factor AP-2 beta in a genetically mixed C57BL/6/129S1 mouse strain resulted in perinatal lethality as a consequence of massively enhanced apoptotic death of renal epithelial cells (Genes Dev 1997;11:1938-1948). Recently, we observed that the phenotype is modulated by genetic background because AP-2 beta mutant mice, backcrossed onto 129P2 background, survive approximately 2 weeks...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 12695560
DOI: 10.1097/01.lab.0000064703.92382.50

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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