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Article

Gfi-1B plays a critical role in terminal differentiation of normal and transformed erythroid progenitor cells

27 Oct 2004

Abstract excerpt

Growth factor independence-1B (Gfi-1B) is a transcription factor with a highly conserved transcriptional repressor snail-Gfi-1 (SNAG) domain and 6 zinc-finger domains at the N- and C-terminus, respectively. Disruption of the Gfi-1B gene is lethal in the embryo with failure to produce definitive enucleated erythrocytes. In this study, we analyzed the role of Gfi-1B in human erythropoiesis. We observed an increase...

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Identifiers

PMID: 15507521
DOI: 10.1182/blood-2003-11-4068

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