Article
A novel mode of Gleevec binding is revealed by the structure of spleen tyrosine kinase.
The Journal of biological chemistry - 31 Dec 2004
Atwell Shane, Adams Jason M, Badger John, Buchanan Michelle D, Feil Ingeborg K, Froning Karen J, Gao Xia, Hendle Jörg, Keegan Kevin, Leon Barbara C, Müller-Dieckmann Hans J, Nienaber Vicki L, Noland Brian W, Post Kai, Rajashankar K R, Ramos Aurora, Russell Marijane, Burley Stephen K, Buchanan Sean G
Abstract excerpt
Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase required for signaling from immunoreceptors in various hematopoietic cells. Phosphorylation of two tyrosine residues in the activation loop of the Syk kinase catalytic domain is necessary for signaling, a phenomenon typical of tyrosine kinase family members. Syk in vitro enzyme activity, however, does not depend on phosphorylation (activation loop...
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