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Article

A myristoyl/phosphotyrosine switch regulates c-Abl.

Cell - 21 Mar 2003

Hantschel Oliver, Nagar Bhushan, Guettler Sebastian, Kretzschmar Jana, Dorey Karel, Kuriyan John, Superti-Furga Giulio

Abstract excerpt

The c-Abl tyrosine kinase is inhibited by mechanisms that are poorly understood. Disruption of these mechanisms in the Bcr-Abl oncoprotein leads to several forms of human leukemia. We found that like Src kinases, c-Abl 1b is activated by phosphotyrosine ligands. Ligand-activated c-Abl is particularly sensitive to the anti-cancer drug STI-571/Gleevec/imatinib (STI-571). The SH2 domain-phosphorylated tail...

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Identifiers

PMID: 12654250
DOI: 10.1016/s0092-8674(03)00191-0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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