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Article

Spleen tyrosine kinase as a molecular target for treatment of leukemias and lymphomas

1 Sept 2010

Abstract excerpt

Spleen tyrosine kinase (SYK) has emerged as a potential molecular target for the treatment of B-lineage leukemias and lymphomas. Here, we provide an overview of the current state of knowledge regarding the regulatory signaling function of SYK and its role in the pathogenesis of B-lineage lymphoid malignancies, available methods and drug candidates for targeting SYK, as well as compelling preclinical and clinical...

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Identifiers

PMID: 20836676
DOI: 10.1586/era.10.112

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