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Article

Spleen tyrosine kinase is overexpressed and represents a potential therapeutic target in chronic lymphocytic leukemia.

Cancer research - 1 Jul 2009

Buchner Maike, Fuchs Simon, Prinz Gabriele, Pfeifer Dietmar, Bartholomé Kilian, Burger Meike, Chevalier Nina, Vallat Laurent, Timmer Jens, Gribben John G, Jumaa Hassan, Veelken Hendrik, Dierks Christine, Zirlik Katja

Abstract excerpt

B-cell receptor signaling contributes to apoptosis resistance in chronic lymphocytic leukemia (CLL), limiting the efficacy of current therapeutic approaches. In this study, we investigated the expression of spleen tyrosine kinase (SYK), a key component of the B-cell receptor signaling pathway, in CLL and its role in apoptosis. Gene expression profiling identified enhanced expression of SYK and downstream pathways...

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Source

Identifiers

PMID: 19549911
DOI: 10.1158/0008-5472.CAN-08-4252

Genes

SYK
ZAP70

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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