Article

Development of SYK NanoBRET Cellular Target Engagement Assays for Gain–of–Function Variants

2024-06-13

Abstract excerpt

Spleen tyrosine kinase (SYK) is a non-receptor tyrosine kinase that is activated by phosphorylation events downstream of FcR, B-cell and T-cell receptors, integrins, and C-type lectin receptors. When the tandem Src homology 2 (SH2) domains of SYK bind to phosphorylated immunoreceptor tyrosine-based activation motifs (pITAMs) contained within these immunoreceptors, or when SYK is phosphorylated in interdomain regio...

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Literature Corpus work: 66b8c0bf-d3ba-50ca-a6d6-6fcb6fe836e8
DOI: 10.1101/2024.06.12.598544

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