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Article

SYK is a critical regulator of FLT3 in acute myeloid leukemia.

Cancer cell - 10 Feb 2014

Puissant Alexandre, Fenouille Nina, Alexe Gabriela, Pikman Yana, Bassil Christopher F, Mehta Swapnil, Du Jinyan, Kazi Julhash U, Luciano Frédéric, Rönnstrand Lars, Kung Andrew L, Aster Jon C, Galinsky Ilene, Stone Richard M, DeAngelo Daniel J, Hemann Michael T, Stegmaier Kimberly

Abstract excerpt

Cooperative dependencies between mutant oncoproteins and wild-type proteins are critical in cancer pathogenesis and therapy resistance. Although spleen tyrosine kinase (SYK) has been implicated in hematologic malignancies, it is rarely mutated. We used kinase activity profiling to identify collab...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to fms-Like Tyrosine Kinase 3

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Share to Leukemia, Myeloid, Acute

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Source

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Identifiers

PMID: 24525236
DOI: 10.1016/j.ccr.2014.01.022
PMCID: PMC4106711

Genes

FLT3
SYK
MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24525236-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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