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Article

Syk protein inhibitors treatment for the allergic symptoms associated with hyper immunoglobulin E syndromes: A focused on a computational approach.

International journal of immunopathology and pharmacology - 1 Jan 2000

Mansouri Mariam, ElHaddoumi Ghyzlane, Kandoussi Ilham, Belyamani Lahcen, Ibrahimi Azeddine, El Hafidi Naima

Abstract excerpt

Background: Mutations in the Spleen tyrosine kinase (Syk) protein have significant implications for its function and response to treatments. Understanding these mutations and identifying new inhibitors can lead to more effective therapies for conditions like autosomal dominant hyper-IgE syndrome (AD-HIES) and related immunological disorders. Objective: To investigate the impact of mutations in the Syk protein on...

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Identifiers

PMID: 39241232
DOI: 10.1177/03946320241282030
PMCID: PMC11380138

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Related research

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Syk protein inhibitors treatment for the allergic symptoms associated with hyper immunoglobulin E syndromes: A focused on a computational approach.PMID 39241232Read ↗

Novel<i>SYK</i>variant causes enhanced SYK autophosphorylation and PI3K activation in an antibody-deficient patientSemantic proximity Read ↗

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The Landscape of Atypical and Eukaryotic Protein Kinases.Semantic proximity Read ↗

Protein stabilization improves STAT3 function in autosomal dominant hyper-IgE syndrome.Semantic proximity Read ↗

JAK3 Y841 Autophosphorylation Is Critical for STAT5B Activation, Kinase Domain Stability and Dimer FormationSemantic proximity Read ↗

Signal Transducer and Activator of Transcription 3 (STAT3) Variant p.K709N Causes Hyper-IgE Syndrome Likely by Impaired STAT3-Dimer Formation.Semantic proximity Read ↗

Saturation mutagenesis of a predicted ancestral Syk-family kinaseSemantic proximity Read ↗

Tofacitinib as a Successful Treatment for Hyper-IgE Syndrome and Autoimmunity Associated with Constitutive Activation of JAK3.Semantic proximity Read ↗

Genome wide analysis of pathogenic SH2 domain mutations.Semantic proximity Read ↗

Gain-of-function variants in SYK cause immune dysregulation and systemic inflammation in humans and mice.Semantic proximity Read ↗

Structural and biophysical characterization of the Syk activation switch.Semantic proximity Read ↗

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