Article

Insight into Janus kinases specificity: From molecular architecture to cancer therapeutics

2024-03-01

Abstract excerpt

Abstract Janus Kinases (JAKs) play a crucial role as therapeutic targets for various cancers. However, the current JAK inhibitors (JAKi) available have limited therapeutic benefits due to their lack of selectivity. This review focuses on the structural analysis to elucidate the molecular determinants of JAKs specificity and the discovery and design of selective JAKi. It includes descriptions and comparison of diff...

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Literature Corpus work: b325d433-c89d-58ee-83b7-0e5c5df6e817
DOI: 10.1002/mog2.69

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