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Article

In vitro evolution of itraconazole resistance in Aspergillus fumigatus involves multiple mechanisms of resistance.

Antimicrobial agents and chemotherapy - 1 Nov 2004

da Silva Ferreira Márcia Eliana, Capellaro José Luiz, dos Reis Marques Everaldo, Malavazi Iran, Perlin David, Park Steven, Anderson James B, Colombo Arnaldo L, Arthington-Skaggs Beth A, Goldman Maria Helena S, Goldman Gustavo H

Abstract excerpt

We investigated the evolution of resistance to the antifungal drug itraconazole in replicate populations of Aspergillus fumigatus that were founded from a strain with a genotype of sensitivity to a single drug and then propagated under uniform conditions. For each population, conidia were serially transferred 10 times to agar medium either with or without itraconazole. After 10 transfers in medium supplemented...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 15504870
DOI: 10.1128/AAC.48.11.4405-4413.2004
PMCID: PMC525395

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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