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Experimental and in-host evolution of triazole resistance in human pathogenic fungi

23 Aug 2022

Abstract excerpt

The leading fungal pathogens causing systemic infections in humans are Candida spp., Aspergillus fumigatus, and Cryptococcus neoformans. The major class of antifungals used to treat such infections are the triazoles, which target the cytochrome P450 lanosterol 14-α-demethylase, encoded by the ERG11 (yeasts)/cyp51A (molds) genes, catalyzing a key step in the ergosterol biosynthetic pathway. Triazole resistance in...

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PMID: 37746192
DOI: 10.3389/ffunb.2022.957577

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