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Article

Multiple resistance mechanisms among Aspergillus fumigatus mutants with high-level resistance to itraconazole.

Antimicrobial agents and chemotherapy - 1 May 2003

Nascimento Adriana M, Goldman Gustavo H, Park Steven, Marras Salvatore A E, Delmas Guillaume, Oza Uma, Lolans Karen, Dudley Michael N, Mann Paul A, Perlin David S

Abstract excerpt

A collection of Aspergillus fumigatus mutants highly resistant to itraconazole (RIT) at 100 micro g ml(-1) were selected in vitro (following UV irradiation as a preliminary step) to investigate mechanisms of drug resistance in this clinically important pathogen. Eight of the RIT mutants were foun...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 12709346
DOI: 10.1128/AAC.47.5.1719-1726.2003
PMCID: PMC153329

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12709346-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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