Article
Directed evolution of the pathogenic mold Aspergillus fumigatus reveals novel genes contributing to triazole resistance.
Antimicrobial agents and chemotherapy - 1 Apr 2026
Handelman Mariana, Sarkar Argha, Varshavsky Avital, Shadkchan Yona, Chen Xuefei, Wright Gerard D, Delbaje Endrews, Laflamme Bradley, Fallah Sara, Côté Evelyne, Robbins Nicole, Fernanda Dos Reis Thaila, Goldman Gustavo H, Cowen Leah E, Osherov Nir
Abstract excerpt
Aspergillus fumigatus is the leading cause of invasive mold infections in immunocompromised patients. Current antifungal treatment primarily depends on the triazole antifungals, which act by inhibiting Erg11/Cyp51, a key enzyme in the ergosterol biosynthetic pathway. However, resistance is emerging at an increasing rate, reducing treatment efficacy and patient survival. Confirmed resistance mechanisms in clinical...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.