NF-kappaB elements associated with the Stat6 site in the germline gamma1 immunoglobulin promoter are not necessary for the transcriptional response to CD40 ligand.

Abstract excerpt

Both germline transcription and switch recombination of heavy chain genes are likely to be regulated by cis elements binding transcription factors in the promoter regions of germline immunoglobulin genes. To identify cis-acting elements important in germline transcription of the murine gamma1 heavy chain gene, we have used a transgenic approach. Seventeen kb gamma1 immunoglobulin transgenes with mutations in...

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