Article
Processing of switch transcripts is required for targeting of antibody class switch recombination.
The Journal of experimental medicine - 21 Dec 1998
Hein K, Lorenz M G, Siebenkotten G, Petry K, Christine R, Radbruch A
Abstract excerpt
Antibody class switching is mediated by somatic recombination between switch regions of the immunoglobulin heavy chain gene locus. Targeting of recombination to particular switch regions is strictly regulated by cytokines through the induction of switch transcripts starting 5' of the repetitive s...
Topics
- Adenoviridae
- Animals
- B-Lymphocytes
- Exons
- Female
- Genetic Vectors
- Genotype
- Immunoglobulin Class Switching
- Immunoglobulin G
- Immunoglobulin Switch Region
- Interleukin-4
- Lipopolysaccharides
- Lymphocyte Activation
- Male
- Mice
- Mice, Inbred Strains
- Mice, Transgenic
- Mutagenesis, Site-Directed