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Article

Processing of switch transcripts is required for targeting of antibody class switch recombination.

The Journal of experimental medicine - 21 Dec 1998

Hein K, Lorenz M G, Siebenkotten G, Petry K, Christine R, Radbruch A

Abstract excerpt

Antibody class switching is mediated by somatic recombination between switch regions of the immunoglobulin heavy chain gene locus. Targeting of recombination to particular switch regions is strictly regulated by cytokines through the induction of switch transcripts starting 5' of the repetitive switch regions. However, switch transcription as such is not sufficient to target switch recombination. This has been...

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Identifiers

PMID: 9858523
DOI: 10.1084/jem.188.12.2369
PMCID: PMC2212419

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Processing of switch transcripts is required for targeting of antibody class switch recombination.PMID 9858523Read ↗

Switch Transcripts in Immunoglobulin Class SwitchingSemantic proximity Read ↗

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NF-kappaB elements associated with the Stat6 site in the germline gamma1 immunoglobulin promoter are not necessary for the transcriptional response to CD40 ligand.Semantic proximity Read ↗

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Germ-line transcription occurs on both the functional and the non-functional alleles of immunoglobulin constant heavy chain genes.Semantic proximity Read ↗

Somatic hypermutation of immunoglobulin genes is linked to transcription initiation.Semantic proximity Read ↗

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